Ionic Lead, but not Other Ionic Metals (Ni^<2+>, Co^<2+> and Cd^<2+>), Suppresses 2-Methoxy-4-aminoazobenzene-Mediated Cytochrome P450IA2 (CYP1A2) Induction in Rat Liver

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概要

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• Male F344 rats were pretreated with lead nitrate, nickel chloride, cobalt chloride or cadmium chloride, and their effects on the induction of cytochrome P450 (CYP) enzymes, mainly CYP1A2 enzyme, with 2-methoxy-4-aminoazobenzene (2-MeO-AAB) in the livers were comparatively examined by enzymatical, immunochemical, and molecular biological methods. When rats were pretreated with each ionic metal, the total CYP amount in the liver microsomes decreased, as compared with that of rats treated with 2-MeO-AAB alone. However, among the ionic metals used only lead reduced the levels of the mRNA and protein of CYP1A2 induced with 2-MeO-AAB in the rat liver, and decreased the microsomal activity (per CYP) for CYP1A2-mediated mutagenesis. Furthermore, ionic lead, but not other ionic metals, showed an ability to induce a placental form of glutathione S-transferase (GST-P). The level of CYP1A2 induced with 2-MeO-AAB was decreased along with increase in that of the induced GST-P.

• 公益社団法人日本薬学会の論文
• 1995-09-15

著者

• 出川 雅邦

  東北大学 薬学部 衛生化学教室

• 久保田 雅子

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University

• 荒井 寛

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University

• 橋本 嘉幸

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University:(present Addre

• 出川 雅邦

  東北大学薬学部

• 出川 雅邦

  Department of Hygienic chemistry, Faculty of Pharmaceutical Sciences, Tohoku University

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• Mutagenicity of Methoxyl Derivatives of N-Hydroxy-4-aminoazobenzene and 4-Nitrozobenzene(Communication)
• Ionic Lead, but not Other Ionic Metals (Ni^, Co^ and Cd^), Suppresses 2-Methoxy-4-aminoazobenzene-Mediated Cytochrome P450IA2 (CYP1A2) Induction in Rat Liver
• Inhibition of the Induction and Activity of Hepatic P450IA Isozymes by in Vivo Administration of Carbon Tetrachloride to Rats
• Electrophilic Reactivity and Mutagenicity of Ring-methyl Derivatives of N-Acyloxy-N-methyl-4-aminoazobenzene and Related Azo Dyes
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• 化学発癌剤の代謝 (化学から見た癌)
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• 化学発癌とチトクロームP450 : 発癌性芳香族アミンによるチトクロームP450誘導と肝発癌
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