New N-N Bond Cleavage of Fused Chloropyridazines with Ynamines

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概要

• 論文の詳細を見る

• 1-Chlorophthalazine (1) reacts with a 2-fold molar excess of ynamines 2a, b to give penta-substituted pyridine derivatives 3a, b by nitrogen-nitrogen bond cleavage of the pyridazine ring with release of hydrogen chloride. Similarly, other fused pyridazines having a chloro substituent α to nitrogen in the pyridazine ring, i.e., pyrido[3,4-d]- (10a), pyrido[2,3-d]- (10b), thiazolo[4,5-d]- (10c, d), furo[2,3-d]- (10e) and pyrrolo[2,3-d]- (10f, g) pyridazine derivatives, gave the corresponding penta-substituted pyridines 11a-11k.

• 社団法人日本薬学会の論文
• 1994-11-15

著者

• 東野 武郎

  School Of Pharmaceutical Sciences University Of Shizuoka

• 丹治 健一

  School of Pharmaceutical Sciences, University of Shizuoka

• 大石 悦男

  Division Of Environmental Health Sciences Graduate School Of Nutritional & Environmental Science

• 大石 悦男

  Laboratory Of Organic Chemistry Graduate School Of Nutritional And Environmental Sciences University

• 岩本 憲人

  School of Pharmaceutical Sciences, University of Shizuoka

• 鈴木 澄子

  School of Pharmaceutical Sciences, University of Shizuoka

• 宮下 晶

  School of Pharmaceutical Sciences, University of Shizuoka

• 岡田 知巳

  Division of Environmental Health Sciences, Graduate School of Nutritional & Environmental Sciences U

• 鈴木 澄子

  School Of Pharmaceutical Sciences University Of Shizuoka

• 鈴木 真也

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tohoku University

• 宮下 晶

  School Of Pharmaceutical Sciences University Of Shizuoka

• 丹治 健一

  School Of Food & Nutritional Sciences University Of Shizuoka

• Suzuki S

  Faculty Of Pharmacy Meiji University

• 岩本 憲人

  静岡県立大学薬学部

• 岡田 知巳

  Division Of Environmental Health Sciences Graduate School Of Nutritional & Environmental Science

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