Catalytic Action of Azolium Salts. I. : Aroylation of 4-Chloro-1H-pyrazolo[3,4-d]pyrimidines with Aromatic Aldehydes Catalyzed by 1,3-Dimethylbenzimidazolium Iodide
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概要
- 論文の詳細を見る
When a mixture of 4-chloro-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine (9), aromatic aldehyde (5), sodium hydride, and a catalytic amount of 1,3-dimethylbenzimidazolium iodide (4) in tetrahydrofuran was refluxed, the nucleophilic aroylation occurred, resulting in the formation of the aryl 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl ketones (11).Similar reaction of 4-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine (10) gave the corresponding aryl 1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl ketones (12) in moderate yields. Use of dimethylformamide or dimethyl sulfoxide in the above reaction reduced the necessary reaction time and reaction temperature. A plausible reaction pathway for the formation of the ketones 11 and 12 involving the catalytic action of 4 is proposed.
- 社団法人日本薬学会の論文
- 1990-05-25
著者
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東野 武郎
School Of Pharmaceutical Sciences University Of Shizuoka
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飯島 千穂子
Shizuoka College of Pharmacy
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松田 秀明
Central Research Laboratories, SS Pharmaceutical Co., Ltd.,
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松田 秀明
Central Research Laboratories S S Pharmaceutical Co. Ltd.
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宮下 晶
School Of Pharmaceutical Sciences University Of Shizuoka
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飯島 千穂子
School of Pharmaceutical Sciences, University of Shizuoka
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飯島 千穂子
School Of Pharmaceutical Sciences University Of Shizuoka
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