Quinoxaline誘導体に関する研究(第20報)2-Alkoxyquinoxaline誘導体とSodium Amideとの反応について

概要

論文の詳細を見る
Application of sodium amide to 2,3-diethoxyquinoxaline (I) and 3-substituted [methoxy (II), isopropyl (V), tert-butyl (VI), phenyl (VII)] 2-methoxyquinoxaline in dehyd. benzene, in the presence of methyl ethyl ketone gives 3-substituted [ethoxy (III), methoxy (IV), isopropyl (VIII), tert-butyl (IX), phenyl (X)] 2-aminoquinoxalines. IV and III are respectively obtained from 2-methoxyquinoxaline (XXVIII) and 2-ethoxyquinoxaline (XXIX) by the same reaction. In the case of 2-ethyl-3-methoxyquinoxaline (XXV), 2,2'-[α, α'-dimethyethylenebis(3-methoxyquinoxaline)] (XXVI) is obtained mainly, with 2-amino-3-ethylquinoxaline (XXVII) as a minor product. In the case of 2-methoxy-3-methylquinoxaline (XVII), IV is obtained contrary to expectations, accompanied by 2,2'-methylenebis(3-methoxyquinoxaline) (XIX), 2,2'-ethylenebis(3-methoxyquinoxaline (XX), and 3-methoxy-3'-methyl-2,2'-methylenediquinoxaline (XXI).
公益社団法人日本薬学会の論文
1975-07-25