環状ヒドラジド構造を含む複素環化合物の合成とその抗腫瘍性について

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概要

• 論文の詳細を見る

• Compounds possessing a cyclic hydrazide structure in their molecule, 2-amino-3-phenyl-1 (2H)-isoquinolinone (I_1), 3-amino-2-(4-methoxyphenyl)-4 (3H)-quinazolinone (II_1), 5-amino-1,5-dihydro-1-phenyl-4H-pyrazolo [3,4-d] pyrimidin-4-one (III_1), 5-amino-1,5-dihydro-1-(2-pyridyl)-4H-pyrazolo [3,4-d] pyrimidin-4-one (IV_1), and 30 kinds of their derivatives were synthesized for antitumor screening. It was found that 5-(benzoylamino)-1,5-dihydro-1-phenyl-4H-pyrazolo [3,4-d] pyrimidin-4-one (III_5) possessed an anti-tumor activity against Sarcoma-180A.

• 社団法人日本薬学会の論文
• 1978-11-25

著者

• 三輪 良雄

  静岡薬科大学

• 大石 悦男

  Division Of Environmental Health Sciences Graduate School Of Nutritional & Environmental Science

• 大石 悦男

  Shizuoka College of Pharmacy

• 岩田 茂子

  静岡薬科大学

• 榑谷 和男

  国立がんセンター研究所

• 飯島 千穂子

  Shizuoka College of Pharmacy

• 林 英作

  School Of Pharmaceutical Sciences University Of Shizuoka

• 星昭 夫

  国立がんセンター研究所薬効試験部

• 榑谷 和男

  Pharmacology Division, National Cancer Center Research Institute

• 榑谷 和男

  Pharmacology Division National Cancer Center Research Institute

• 槫谷 和男

  Pharmacology Division National Cancer Center Research Institute

• 飯島 千穂子

  School of Pharmaceutical Sciences, University of Shizuoka

• 飯島 千穂子

  静岡薬科大学

• 飯島 千穂子

  School Of Pharmaceutical Sciences University Of Shizuoka

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