Triazolo [4,5-d] pyrimidines. IV. The Grignard Reaction of 3-Substituted 3H-1,2,3-Triazolo [4,5-d] pyrimidines

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概要

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• Grignard reactions of 3-methyl- (1m) and 3-phenyl-3H-1,2,3-triazolo [4,5-d] pyrimidine (1p) resulted in the formation of 7-alkyl-6,7-dihydro-3-methyl- (2m) and 7-alkyl-6,7-dihydro-3-phenyl-3H-1,2,3-triazolo [4,5-d] pyrimidines (2p) in moderate yields. These dihydro compounds 2m and 2p were converted into 7-alkyl-3-methyl- (3m) and 7-alkyl-3-phenyl-3H-1,2,3-triazolo [4,5-d] pyrimidines (3p), respectively, by oxidation with potassium ferricyanide.

• 公益社団法人日本薬学会の論文
• 1979-12-25

著者

• 林 英作

  Shizuoka College of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

• 林 英作

  School Of Pharmaceutical Sciences University Of Shizuoka

• 香取 達彦

  Central Research Laboratories, SS Pharmaceutical Co., Ltd.

• 吉田 静生

  静岡薬科大学

• 香取 達彦

  Central Research Laboratories S S Pharmaceutical Co. Ltd.

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