Studies on the Reaction of Quinazoline 3-Oxide with Ketone. The Transformation of Quinazoline 3-Oxide into Quinoline Derivatives

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概要

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• The direct reaction of quinazoline 3-oxide (I) with ketones (III) without a base was carried and resulted in the transformation of I into quinoline derivatives (II), although the yields of II were very poor (small percentage) in some cases. Thus, the reaction of I with acetophenone gave 2-phenylquinoline (II-3), quinazoline (IV) and 4,4'-biquinazoline (V), with propiophenone, 3-methyl-2-phenylquinoline (II-4) and V, with acetone, 2-methylquinoline (II-5), IV, V, and 2-aminobenzaldoxime (VI), with 3-pentanone, 2-ethyl-3-methylquinoline (II-6), IV and VI, with 2-butanone, 2,3-dimethylquinoline (II-7) and IV, with 2-pentanone, 3-ethyl-2-methylquinoline (II-8), IV and VI, with 3-methyl-2-butanone, 2-isopropylquinoline (II-9), IV and 4-methylquinazoline 3-oxide (VII), with 3,3-dimethyl-2-butanone, 2-tert-butylquinoline (II-10), IV, V, and VII, with 4-methyl-2-pentanone, 2-isobutylquinoline (II-11), IV and V, with cyclopentanone, 2,3-dihydro-1H-cyclopenta [b] quinoline (II-12), with cyclohexanone, 1,2,3,4-tetrahydroacridine (II-13), respectively.

• 公益社団法人日本薬学会の論文
• 1975-04-25

著者

• 林 英作

  Shizuoka College of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

• 鈴木 清

  Shizuoka College of Pharmacy

関連論文

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