The Transformation of Pyrido [2,3-d] pyrimidine into 1,8-Naphthyridine
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概要
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The reaction of pyrido [2,3-d] pyrimidine (1) with active methylene compounds and ketones (NuH) were carried out, and resulted in the formation of 1,8-naphthyridines. Thus, the reaction with acetophenone (NuH-1), propiophenone (NuH-2), butyrophenone (NuH-3), cyclopentanone (NuH-4), cyclohexanone (NuH-5), malononitrile (NuH-6), and ethyl cyanoacetate (NuH-7) gave 2-phenyl-(2-1), 3-methyl-2-phenyl-(2-2), 3-ethyl-2-phenyl-1,8-naphthyridine (2-3), 7,8-dihydro-6H-cyclopenta [b] [1,8] naphthyridine (2-4), 6,7,8,9-tetrahydrobenzo [b] [1,8] naphthyridine (2-5), 2-amino-1,8-naphthyridine-3-carbonitrile (2-6), and ethyl 2-amino-1,8-naphthyridine-3-carboxylate (2-7), respectively. And the possible reaction mechanism was proposed.
- 公益社団法人日本薬学会の論文
- 1978-10-25
著者
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林 英作
Shizuoka College of Pharmacy
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東野 武郎
Shizuoka College of Pharmacy
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林 英作
School Of Pharmaceutical Sciences University Of Shizuoka
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鈴木 清
Shizuoka College of Pharmacy
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