Gel Filtration of Solubilized Systems. VII. Temperature Effect on the Solubilization of Ethylparaben in Hexaoxyethylene Lauryl Ether Micelles

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概要

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• The effect of temperature on the solubilization of ethyl p-hydroxybenzoate (ethylparaben) in hexaoxyethylene lauryl ether (C_<12>E_6) micelles was examined by the gel filtration method using Sephadex G-200. The values of standard Gibbs energy (ΔG^〓), enthalpy (ΔH^〓) and entropy (ΔS^〓) changes for the micellar solubilization of ethylparaben were calculated, together with the interaction energy parameter (ω). The negative values of ΔH^〓 and ω showed that there is an interaction between the phenolic OH group in ethylparaben and the polyoxyethylene groups in the C_<12>E_6 micellar phase. The positive values of ΔS^〓 suggest that the alkane moiety of ethylparaben is incorporated into the hydrocarbon core of C_<12>E_6 micelles. These results showed that both enthalpy and entropy effects control the micellar solubilization of ethylparaben.

• 社団法人日本薬学会の論文
• 1984-08-25

著者

• 東野 武郎

  School Of Pharmaceutical Sciences University Of Shizuoka

• 五島 綾子

  Shizuoka College Of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

• 遠藤 文男

  Shizuoka College of Pharmacy

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