Mass Spectra of 3-Alkyl-4-cinnolinecarbonitriles

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概要

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• Mass spectra (MS) of 3-alkyl-4-cinnolinecarbonitrile (I) were examined. In MS of I, (M-・H)^+ species are encountered only to a minor extent in the lower one in contrast with (M-・N_2H)^+ species. In particular it is worth noting that (M-・H)^+ species are not found in MS of 3-methy1-(Ib) and 3-ethyl-4-cinnolinecarbonitrile (Ic). When the alkyl substituent at the 3-position of I such as methyl (Ib), ethyl (Ic), and propyl (Id), is not so bulky, the important fragmentation arises from the initial expulsion of ・N_2H radical from M^+. In turn, when the alkyl substituent is bulkier than that of isopropyl, the importance of this process is not recognized as seen in MS of 3-isopropyl-(Ie) and 3-butyl-4-cinnolinecarbonitrile (If). Those facts mentioned above mean that the ring cleavage of I by the initial expulsion of ・N_2H radical is dependent on the relative size of the alkyl substituent at the 3-position.

• 公益社団法人日本薬学会の論文
• 1977-09-25

著者

• 内田 三夫

  Shizuoka College of Pharmacy

• 林 英作

  Shizuoka College of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

関連論文

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