Purines. V. Reaction of 9-Phenyl-9H-purine-6-carbonitrile with Nucleophilic Reagents

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概要

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• The reaction of 9-phenyl-9H-purine-6-carbonitrile (1) with nucleophilic reagents occurred by addition of the reagent across the C-N triple bond of the cyano group, and substitution of the cyano group was not observed. Thus, the reactions with hydroxylamine, hydrazine, amines, Grignard reagents, and 98% sulfuric acid gave the corresponding amidoxime (2), amidorazone (3), amidines (4), ketones (5), and amide (7), respectively. Alcoholysis of 1 gave the ester (6) and 7 together with the ring fission product of the imidazole portion, alkyl 5-amino-6-anilino-4-pyrimidine-carboxylate (8). Amides (10), the hydroxamic acid (11), and the hydrazide (12) were prepared from the methyl ester (6a).

• 公益社団法人日本薬学会の論文
• 1982-12-25

著者

• 林 英作

  Shizuoka College of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

• 林 英作

  School Of Pharmaceutical Sciences University Of Shizuoka

• 吉田 静生

  静岡薬科大学

• 吉田 静生

  Shizuoka College of Pharmacy

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