Catalytic Reduction of Heterocyclic Aromatic Amine Oxides with Raney Nickel. I. Reduction of 4-Substituted Pyridine 1-Oxide Derivatives.

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概要

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• Catalytic reduction of various 4-substituted pyridine 1-oxides in neutral medium, with Raney nickel as a catalyst, was carried out at ordinary temperature and pressure. It was thereby found that N-oxide group in these compounds was selectively reduced, irrespective of the substituent in 4-position, and the products were obtained in a good yield of 85〜98%. 4-Nitropyridine 1-oxide afforded 90% of 4-aminopyridine in acetic acid medium and 4-benzyloxypyridine 1-oxide afforded 93% of 4-hydroxypyridine in one step when reduced over a mixed catalyst of palladium-carbon and Raney nickel. It was considered that this process of reduction is the best method for laboratory preparation of 4-substituted pyridines.

• 公益社団法人日本薬学会の論文
• 1959-03-20

著者

• 清水 和子

  Shizuoka College Of Pharmacy

• 林 英作

  Shizuoka College of Pharmacy

• 山中 宏

  Shizuoka College of Pharmacy

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