On the Reactivity of 2,6-Dimethyl-pyrimidine-4-carbonitrile.
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Reactivity of cyano group in 4-position of 2,6-dimethylpyrimidine-4-carbonitrile was examined. This compound behaves like ordinary nitriles in forming 4-acetyl compound with methylmagnesium bromide, 4-carboxylic acid ester with dehydrated alcohol and hydrogen chloride, and 4-acid amide with alkaline hydrogen peroxide. However, it showed specificity in undergoing substitution with methoxyl ion to form 4-methoxy compound. The ester or acid amide obtained by such reaction was reacted with hydrazine hydrate to afford 2,6-dimethylpyrimidine-4-carbohydrazide. Condensation with few other aldehydes was also carried out.
- 公益社団法人日本薬学会の論文
- 1958-12-15
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