Catalytic Reduction of Heterocyclic Aromatic Amine Oxides with Raney Nickel. III. Reduction of Hydroxamic Acid-type N-Oxides.

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概要

• 論文の詳細を見る

• In the catalytic reduction of hydroxamic acid and compounds possessing hydroxyl adjacent to the N-oxide group and forming a hydroxamic acid-type structure, Raney nickel catalyst was found to act specifically in severing the nitrogen-oxygen bond. 2-Hydroxyquinoline 1-oxide, 4-methoxy-and 4-ethoxy-2-hydroxyquinazoline 1-oxide, and benzohydroxamic acid were deoxygenated forming 2-hydroxyquinoline, 4-methoxy- and 4-ethoxy-2-hydroxyquinazoline, and benzamide. In 4-benzyloxy-2-hydroxyquinazoline 1-oxide, the reduction of benzyloxyl group preceded the reduction of N-oxide group and 2,4-dihydroxyquinazoline was formed via its 1-oxide compound.

• 公益社団法人日本薬学会の論文
• 1959-03-20

著者

• 林 英作

  Shizuoka College of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

• 山中 宏

  Shizuoka College of Pharmacy

関連論文

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