Condensed Pyridazines. VI. Reaction of 7-(Methylsulfonyl)-1-phenyl-1H,2,3-triazolo[4,5-d]pyridazine with Carbanions and Enamines(Organic,Chemical)

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概要

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• The reaction of 7-(methylsulfonyl)-1-phenyl-1H-1,2,3-triazolo[4,5-d]pyridazine (1) with active methylene compounds or ketones(3a-g) in the presence of sodium hydride gave the corresponding 7-substituted 1-phenyl-1H-1,2,3-triazolo[4,5-d]pyridazines(4a-g). A [4+2] cycloaddition occurred in the reaction with enamines or ynamines(9a-d) to give the corresponding arenotriazoles(10a-d). Similarly, the reaction of 7-chloro-1-phenyl-1H-1,2,3-triazolo[4,5-d]pyridazine (2) with 3 and 9 resulted in the formation of 4 and arenotriazoles (12), respectively.

• 社団法人日本薬学会の論文
• 1987-07-25

著者

• 東野 武郎

  School Of Pharmaceutical Sciences University Of Shizuoka

• 大石 悦男

  Division Of Environmental Health Sciences Graduate School Of Nutritional & Environmental Science

• 大石 悦男

  Shizuoka College of Pharmacy

• 山田 晶哉

  Shizuoka College of Pharmacy

• 林 英作

  Shizuoka College of Pharmacy

• 東野 武郎

  Shizuoka College of Pharmacy

• 林 英作

  School Of Pharmaceutical Sciences University Of Shizuoka

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