Condensed Pyridazines. VIII. Reaction of Diazolopyridazines with Ynamine. Formation of Ben-zodiazoles and Diazolodiazocines

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概要

• 論文の詳細を見る

• Reaction of the 7-(methylsulfonyl)-1H-imidazo[4,5-d]pyridazine (3) with 1-(N, N-diethylamino)-1-propyne (2) resulted in the formationo f the benzimidazole (5) and the 3H-imidazo[4,5-d][1,2]diazocine (4) through the [4+2]- and [2+2]-cycloadducts. Similarly, reaction of the 7-(methylsulfonyl)-(9) and the 7-cyano-1H-pyrazolo[3,4-d]pyridazines (10) with 2 gave the corresponding indazoles (14,16) and the 1H-pyrazolo[3,4-d][1,2]diazocines (15,17). A similar reaction was also found to proceed between 7-(methylsulfonyl)-1H-1,2,3-triazolo[4,5-d]pyridazine (18) and 2,affording the corresponding benzotriazole (20) and the 3H-1,2,3-triazolo[4,5-d][1,2]diazocine (19).

• 社団法人日本薬学会の論文
• 1991-07-25

著者

• 東野 武郎

  School Of Pharmaceutical Sciences University Of Shizuoka

• 丹治 健一

  School of Pharmaceutical Sciences, University of Shizuoka

• 大石 悦男

  Division Of Environmental Health Sciences Graduate School Of Nutritional & Environmental Science

• 大石 悦男

  Laboratory Of Organic Chemistry Graduate School Of Nutritional And Environmental Sciences University

• 宮下 晶

  School of Pharmaceutical Sciences, University of Shizuoka

• 大石 悦男

  School of Pharmaceutical Sciences, University of Shizuoka

• 泰道 直方

  Central Research Laboratories, S S Pharmaceutical Co., Led.,

• 佐藤 進

  Central Research Laboratories, S S Pharmaceutical Co., Ltd.,

• 太田 昭二

  School of Pharmaceutical Sciences, University of Shizuoka

• 石田 均司

  School of Pharmaceutical Sciences, University of Shizuoka

• 宮下 晶

  School Of Pharmaceutical Sciences University Of Shizuoka

• 佐藤 進

  Department Of Pharmacology Pharmaceutical Institute Tohoku University

• 丹治 健一

  School Of Food & Nutritional Sciences University Of Shizuoka

• 石田 均司

  School Of Pharmaceutical Sciences University Of Shizuoka

• 太田 昭二

  School Of Pharmaceutical Sciences University Of Shizuoka

• 泰道 直方

  Central Research Laboratories S S Pharmaceutical Co.

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