The Adrenergic Neurone Blocking Action of [2-(Methylphenylamino)-ethyl] guanidine Sulfate. II.

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概要

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• [2-(Methylphenylamino) ethyl] guanidine sulfate (MPG) was found to be an effective antihypertensive agent during repeated administration at 10mg./kg. subcutaneously to conscious renal hypertensive rats. Prolonged reduction of contractions evoked by preganglionic stimulation of the cervical sympathetic nerve in the nictitating membrane of cat was observed following a single intravenous administration of 10mg./kg. of MPG. This procedure also caused the potentiation of norepinephrine-induced responses and suppression of tyramineor amphetamine-induced response in the nictitating membrane of the cat and blood pressure of the dog. In the experiment of intra-arterial administration, the postganglionic cervical sympathetic nerve blocking activity was observed to be one-half as potent as guanethidine in the nictitating membrane of cat. The hypotensive effect of MPG would be considered to be depletion of catecholamines and blockade of sympathetic transmission at adrenergic nerve level.

• 公益社団法人日本薬学会の論文
• 1967-06-25

著者

• 小澤 光

  Pharmaceutical Institute Tohoku University

• 佐藤 進

  Department Of Pharmacology Pharmaceutical Institute Tohoku University

• 佐藤 進

  Pharmaceutical Institute, Tohoku University School of Medicine

• 佐藤 進

  Pharmaceutical Institute Tohoku University School Of Medicine

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