Pharmacological Studies on Guanethidine Derivatives. IV. Adrenergic Neurone Blocking Action of 2,3,4,5-Tetrahydro-1H-2-benzazepine-2-carboxamidine Sulfate.
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概要
- 論文の詳細を見る
Pharmacological properties of 2,3,4,5-tetrahydro-1H-2-benzazepine-2-carboxamidine sulfate (GQ-1) has been studied mainly on sympathetic nervous system and the following results were obtained : 1) GQ-1 showed the adrenergic neurone blocking activity three-fifth as potent as that of guanethidine in urethane anesthetized cat nictitating membrane. 2) Unlike with the cases of guanethidine and guanisoquin, GQ-1 did not cause the contraction of the nictitating membrane nor did the rise of the blood pressure in urethane anesthetized cat. 3) GQ-1 potentiated the pressor response to norepinephrine and markedly suppressed the pressor response to tyramine in cat.
- 公益社団法人日本薬学会の論文
- 1967-12-25
著者
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小澤 光
Pharmaceutical Institute Tohoku University
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大槻 勲夫
Pharmaceutical Institute Tohoku University School Of Medicine
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