Pharmacokinetic Investigation of 17α-Desoxymethasone (A 41 304) in Rats

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^3H-A 41 304 ointment in the concentration of 0.27% was applied to the back skin of rats, and its absorption and distribution in the blood and organs and its excretion in the urine and feces were examined in the course of time. 1. Most of the total amount absorbed was excreted in the urine of male and female rats within 1-2 days after the beginning of the application and the excretion in the feces was slightly slower than in the urine. The ratio of the excreted amount in the feces to that in the urine was approximately 1 : 4. 2. There was a sex difference in the total amount of the excreted radioactivity for 7 days after the beginning of the application ; the amount in female rats was only about 60% of that in male ones. The excreted amount was decreased significantly by castration in male rats. The investigation with thin-layer chromatography. revealed that approximately half the absorbed amount of the compound was excreted unchanged in the urine and that the percentage was higher in female rats than in male ones. 3. The radioactivity began to appear in the blood from about 1 hr after the beginning of the application. The maximum radioactivity level was noted in the blood at 24 hr and in main organs at 31 hr. The radioactivity was little detected 7 days after the beginning of the application. 4. The liver and adrenal had higher radioactivity levels than other organs. In each organ the radioactivity reached its maximum 31 hr after the beginning of the application. No sex difference was noted in the distribution of this compound in the organs.
公益社団法人日本薬学会の論文
1974-12-25

Pharmacokinetic Investigation of 17α-Desoxymethasone (A 41 304) in Rats

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