Antagonistic Phenomena between Crystalline Tetrodotoxin and Guanidines on Sympathetic Nervous Systems

概要

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The antagonistic phenomena between crystalline tetrodotoxin and guanidine in the sympathetic nerve-smooth muscle preparations were investigated and the following results were obtained. In the hypogastric nerve-vas deferens preparation of the guinea-pig, the contractions of the vas deferens induced by the electrical stimulation of the pre- and post-ganglionic fiber of the hypogastric nerve were suppressed after the administrations of crystalline tetrodotoxin 5×10^<-8>M and procaine 10^<-4>M, and the suppression by tetrodotoxin was antagonized by guanidine 10^<-3>M or methylguanidine 10^<-3>M, and that by procaine was only temporally antagonized. These antagonistic phenomena were observed also on the guinea-pig trachea preparation and the nictitating membrane of cat. In the hypogastric nerve-vas deferens preparation of the guinea-pig, moreover, the contraction which could not be observed in the absence of Na^+ in the external solution was recovered by applying guanidine into the solution. From these results, it is concluded that tetrodotoxin and guanidine or methylguanidine would be antagonistic at the presynaptic site of sympathetic nerve ending.
社団法人日本薬学会の論文
1969-08-25