Biochemical Studies on Quinone Derivatives. II. Effects of Naturally Occurring Benzoquinone Derivatives on the Respiration of Intact Rat Liver Mitochondria.

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概要

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• Effects of naturally occurring benzoquinone derivatives on rat liver mitochondrial respiration were examined manometrically and polarographically comparing with ubiquinone-0. Dihydroxythymoquinone, helicobasidin, and dihydroperezone were found to show significant effect on the respiration. At the concentration of 1.0×10^<-5>M, dihydroxythymoquinone eliminated the State-3 respiration completely and the for 50% inhibition of the State-3 respiration it required the concentration of 3.2×10^<-6>M. Helicobasidin was an uncoupler and dihydroperezone showed both an uncoupling action on State-4 respiration and an inhibitory action of State-3 respiration. The other benzoquinone derivatives examined did not show any significant effects on mitochondrial respiration.

• 社団法人日本薬学会の論文
• 1967-08-25

著者

• 百瀬 和享

  東北大学医学部薬学科

• 名取 信策

  National Institute of Hygienic Sciences

• 小澤 光

  Pharmaceutical Institute Tohoku University

• 名取 信策

  Meiji College of Pharmacy

• 名取 信策

  National Institute Of Hygienic Sciences:(present Address)meiji College Of Pharmacy

• 百瀬 和享

  National Institute of Hygienic Science

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