General Pharmacological Actions of N-Acetoacetyl-3-hydroxytyrosine

スポンサーリンク

概要

• 論文の詳細を見る

• The general pharmacological actions of N-acetoacetyl-3-hydroxytyrosine (L-DOPA acetoacetate) were investigated and compared with those of L-3,4-dihydroxypenylalanine (L-DOPA). The following results were obtained. 1) L-DOPA acetoacetate and L-DOPA suppressed slightly the spontaneous motor activity in mice. 2) L-DOPA acetoacetate and L-DOPA showed no effect on the sleeping time induced by hexobarbital and on maximal electroshock-, pentetrazol- and strychnine-convulsions in mice, but maximal electroshock convulsion was inhibited by the combined administration of L-DOPA and a monoamine oxidase inhibitor, pargyline. 3) L-DOPA acetoacetate and L-DOPA suppressed the squirming induced by acetic acid in mice. 4) L-DOPA acetoacetate did not have a hypothermic action in mice although L-DOPA did slightly. 5) In anaesthetized rats, L-DOPA acetoacetate and L-DOPA produced a slight temporary rise in the blood pressure and potentiated the pressor actions of norepinephrine and tyramine. The tyramine-induced tachyphylaxis and the abolishment of the response of tyramine induced with reserpine pretreatment were restored by both compounds. 6) On the isolated smooth muscle preparations such as guinea-pig vas deferens, intestine, aorta, rabbit aorta and rat uterus, the contractions induced by several agonists were almost unaffected by L-DOPA acetoacetate and L-DOPA. On guinea-pig vas deferens, aorta and rabbit aorta preparations, however, the tyramine-induced tachyphylaxis and the abolishment of the response of tyramine induced with reserpine pretreatment were restored by both compounds. These restorations were not observed by the treatment of a peripheral DOPA decarboxylase inhibitor, Ro4-4602. These actions were also found on guinea-pig atria preparations. Furthermore, on rat uterus preparations, both compounds increased the spontaneous motility. 7) On the gastrointestinal propulsion in mice and on the isolated skeletal muscle preparations in frog, L-DOPA acetoacetate and L-DOPA showed no effect. From the results mentioned above, it could be assumed that L-DOPA acetoacetate possessed only peripheral without central action though L-DOPA possessed both of central and peripheral actions, and that the activities would be due to their metabolites.

• 社団法人日本薬学会の論文
• 1975-09-25

著者

• 菅原 和信

  Pharmaceutical Institute Tohoku University

• 小澤 光

  Pharmaceutical Institute, Tohoku University

• 厚井 麻里

  Pharmaceutical Institute, Tohoku University

• 加藤 鉄三

  Pharmaceutical Institute, Tohoku University

• 小澤 光

  Pharmaceutical Institute Tohoku University

• 加藤 鉄三

  Pharmaceutical Institute Tohoku University

• 厚井 麻里

  Pharmaceutical Institute Tohoku University

関連論文

• Diketeneより誘導された化合物, ならびに関連化合物の抗腫瘍性スクリーニング
• General Pharmacological Actions of N-Acetoacetyl-3-hydroxytyrosine
• Ganglion Blocking Activity of Amidinothiocholine Derivatives
• Effects of Hexylguanidine on Cardiovascular System and Blood Glucose
• Cocaine-like Action of Hexylguanidine on Smooth Muscle Preparations
• Antagonistic Phenomena between Crystalline Tetrodotoxin and Guanidines on Sympathetic Nervous Systems
• Structure-activity Relationship of Alkylguanidines on Smooth Muscle Organs
• Studies on Ketene and Its Derivatives. XCV. Reaction of Diketene with Acyl Azides
• Synthesis of dl-Dehydroiridodiol
• Studies on Ketene and Its Derivatives. CI. Reaction of Diketene with 4-Amino-methylpyridine 1-Oxides
• Synthesis of Dihydrojasmone and cis-Jasmone
• Reaction of Ethyl 4-Halo-3-oxobutanoate with Diethyl Malonate, Methyl Cyanoacetate, and Malononitrile
• Studies on Ketene and Its Derivatives. LXXXV. Reactions of 4-Bromo-3-hydroxybutanoate and Its Acyl Derivatives
• Synthesis of Methylpyridine Derivatives. XXX. Reaction of Active Methylene Compounds with 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one and 2-Ethoxy-2,6-dimethyl-2H-1,3-oxazin-4 (3H)-one to give 3-Acetylpyridone Derivatives
• Studies on Ketene and Its Derivatives. LVII. Reaction of Diketene with β-Diketones
• Studies on Ketene and Its Derivatives. LIV. Reaction of Diketene with Ketene Acetals
• Studies on Ketene and Its Derivatives. XVIII. Reaction of Diketene with Acridine.
• Studies on Ketene and Its Derivatives. XVII. Reaction of Diketene with Imidates.
• Studies on Ketene and Its Derivatives. XI. Reaction of Diketene with Phenanthridine
• Studies on Ketene and its Derivatives. X. Reaction of Diketene with Schiff Base
• Biochemical Studies on Quinone Derivatives. II. Effects of Naturally Occurring Benzoquinone Derivatives on the Respiration of Intact Rat Liver Mitochondria.
• Biochemical Studies on Quinone Derivatives. I. Effects of Naturally Occurring Benzoquinone Derivatives on Mitochondrial Preparations
• Reaction of Ethyl 4-Bromoacetoacetate with Carbon Disulfide and Active Methylene Compounds
• Neighboring Group Participation of the N-Oxide Group in the Reaction of Methyl 1-Oxido-2-pyridyl Ketone Oxime with Tosyl Chloride
• Reaction of 4-Haloacetoacetate with Phenols in the Presence of Aluminum Chloride
• Studies on Ketene and Its Derivatives. CVII. Photoreaction of Diketene with 6-Methyluracil
• Studies on Ketene and Its Derivatives. CVI. Photoreaction of Diketene with N-Phenylmaleimide and Dimethyl-N-phenylmaleimide
• Studies on Ketene and Its Derivatives. CII. Reaction of Diketene with Cyanamide Derivatives
• Studies on Ketene and Its Derivatives. XCVII. Photoreactions of Diketene with Maleic Anhydride and Dimethylmaleic Anhydride
• Studies on Ketene and Its Derivatives. XCVI. Synthesis of Pyrido [2,1-b] benzoazoles
• Reaction of Ethyl Acetoacetate with Isoquinolinium and Pyridinium Ylides
• Synthesis of Methylpyridine Derivatives. XXXII. Reaction of Pyridine, Quinoline, and Isoquinoline with 4-Bromoacetoacetic Acid Derivatives and Synthesis of Indolizine Derivatives
• Reaction of Diazomethane with 2-Acetyl-5,5-diphenyl-2,4-pentadienoic Acid and Related Compounds
• Studies on Ketene and Its Derivatives. LXXXIV. Reaction of Diketene with Tetrazole Derivatives
• Studies on Ketene and Its Derivatives. LXXVII. Reaction of Diketene with Pyridineformimidates and Related Compounds to give 1,3-Oxazin-4-one Derivatives
• Studies on Ketene and Its Derivatives. LXXV. Reaction of Diketene with N-Benzylacetimidate and Lactim Ethers to give 1,6-Naphthyridine Derivatives
• Studies on 3,7-Dimethyl-1-(5-oxo-hexyl)-xanthine (BL 191). III. Effects of BL 191 and Its Metabolites on Cyclic 3', 5'-Nucleotide Phosphodiesterase and Lipolytic Activities
• Antispasmodic Action of 1-Diethylaminoethyl-3-(p-methoxybenzyl)-2-quinoxalone (P 201-1) and Its Inhibitory Effect on Cyclic 3', 5'-Nucleotide Phosphodiesterase (PDE) Activity
• Pharmacokinetic Investigation of 17α-Desoxymethasone (A 41 304) in Rats
• Studies on 3,7-Dimethyl-1-(5-oxo-hexyl)-xanthine (BL 191). I. Cyclic 3', 5'-Nucleotide Phosphodiesterase (PDE) and the Inhibitory Effect of BL 191 on PDE in Rat Brain and Heart
• A Simple Method for Evaluating Analgesic Efficacy of Non-Steroidal Anti-Inflammatory Drugs
• Syntheses and Activities of Bioquinone Substances. I. Total Syntheses of Rhodoquinones
• Copper DL-Methionine, a New Anthelmintic for Swine Lung Worm. The Action of Copper DL-Methionine on Lung Worms.
• Reaction of β-Aminocrotonamide with N-Acylated Amino Acid Esters to give 2-Acylaminoalkyl-6-methylpyrimidin-4 (3H)-ones and Their Ring Closure with Polyphosphoric Acid (PPA)
• Ring Transformation of 5-Oxo-4-oxaspiro [2.3] hexanes
• Studies on Ketene and Its Derivatives. XCIV. Reaction of Diketene with Diazoacetone and 2-Diazoesters
• Chemical Reactions of Bikaverin
• Studies on Ketene and Its Derivatives. LIII. Reaction of Diketene with Diazoacetophenone and Ethyl Diazoacetate
• Studies on Ketene and Its Derivatives. XLVIII. Reaction of Diketene with Hydroxylamine
• Studies on Ketene and Its Derivatives. XLVII. Reaction of 2-Aminopyridine with Diketene
• Studies on Ketene and Its Derivatives. XLVI. Mass Spectrometric Studies of 3-Acetyl-4-hydroxy-6-methyl-1-pyridyl-2-pyridones and N-Pyridyl-2,6-dimethyl-4-pyrone-3-carboxamides
• Activation of Adenyl Cyclase and Adenosine 3', 5'-Monophosphate Phosphodiesterase in Rat Brain Synaptosomes
• The Stimulation of Synaptosomal Adenyl Cyclase Activity by the Supernatant from Rat Brain Cerebral Cortex
• Endogenous Inhibitor (s) in Rat Liver of Dopamine β-Hydroxylase
• Pharmacological Studies of Troponoids. IV. Antipyretic Analgesic, and Anti-inflammatory Activities of Aminotroponoids
• Studies on Ketene and Its Derivatives. LX. Reaction of Diketene with Quinoline 1-Oxide (Supplement)
• Synthesis of Methylpyridine Derivatives. XXVII. Synthesis of 1,3-Disubstituted-4-oxo-quinolizine and 2,4-Disubstituted-1-oxo-benzo [c] quinolizine Derivatives
• Studies on Ketene and Its Derivatives. XLIX. Reaction of Diketene with β-Ketoesters to give Ethyl Orsellinate, Divarate, Olivetol Carboxylate, and Sphaeropherol Carboxylate
• Synthesis of N-Acylacetoacetamide using 2,2,6-Trimethyl-1,3-dioxin-4-one
• Studies on Ketene and Its Derivatives. CV. Photoreaction of Diketene with sec-Alcohols
• Synthesis of Methylpyridine Derivatives. XXXIV. Condensation of Acetoacetamide with Ketones to form Pyridone Derivatives
• Studies on Ketene and Its Derivatives. XCII. Reaction of Diketene with Benzaldehyde, Cinnamaldehyde, and β-Phenylcinnamaldehyde
• Studies on Ketene and Its Derivatives. LXXXVII. Photoreaction of Diketene with 3-Acetoxy-5,5-dimethyl-2-cyclohexenone
• Studies on Ketene and Its Derivatives. LXVII. Photoreaction of Benzophenone and Benzaldehyde with Diketene
• Pharmacological Studies on Guanethidine Derivatives. IV. Adrenergic Neurone Blocking Action of 2,3,4,5-Tetrahydro-1H-2-benzazepine-2-carboxamidine Sulfate.
• Structure of the Product from the Reaction of Acetonedicarboxylic Acid with Acetic Anhydride
• Studies on Ketene and its Derivatives. VI. Reaction of Diketene with Aminopyridines and their N-Oxides
• Studies on Ketene and Its Derivatives. XXVIII. Reaction of β-Aminocrotonamide with Ketene and Diketene
• Biochemical Studies on Benzoquinone Derivatives. III. Effects of Dihydroxythymoquinone on Rat Liver Mitochondria in the Electron Transport System.
• The Adrenergic Neurone Blocking Action of [2-(Methylphenylamino)-ethyl] guanidine Sulfate. II.
• Reaction of Methyl 1-Oxido-2-pyridyl Ketone Oxime with Acetic Anhydride : Formation of a 3-Methylisoxazolo[4,5-b]pyridine Derivative(Organic,Chemical)
• Reaction of γ-Bromoacetoacetyl Compounds with Benzamide Oxime Derivatives : Synthesis of 4H-1,2,4-Oxadiazine Derivatives
• Cyclization of O-Acetoacetylbenzamide Oxime Derivatives
• Reaction of N-Hydroxyacetoacetanilide with Carbonyl Reagents
• Organic Sulfites containing a 1,2-Oxazine Ring
• Reaction of γ-Bromoacetoacetyl Bromide with N-Phenylhydroxylamine Derivatives : Synthesis of 1,2-Oxazine Derivatives
• Studies on Ketene and Its Derivatives. LXXIX. Reaction of Diketene with Benzimidazole and 2-Methylbenzimidazole Derivatives
• Studies on Ketene and Its Derivatives. LXXXII. Reaction of Diketene with N-Phenylhydroxylamine Derivatives
• Studies on Ketene and Its Derivatives. LXXXI. Reaction of β-Aminocrotonamide with α, β-Unsaturated Ketones
• Studies on Ketene and Its Derivatives. LXXVI. Reactions of Acetoacetamide and β-Aminocrotonamide with β-Diketone, β-Ketoaldehyde and Related Compounds
• Studies on Ketene and Its Derivatives. LXXIV. Carroll Reaction of 1,1-Diphenyl-2-propynyl Acetoacetate
• Studies on Ketene and Its Derivatives. LXXIII. Synthesis of Pyrido [1,2-a]-pyrimidin-4-one and Pyrido [1,2-a] sym-triazin-4-one Derivatives
• Synthesis of Methylpyridine Derivative. XXXI. Reaction of Aceto-acetamide with α, β-Unsturated Ketones and Aldehydes
• Studies on Ketene and Its Derivatives. LXVIII. Reaction of Diketene with N-Imino-pyridinium, -quinolinium, and -isoquinolium Ylides
• Studies on Ketene and Its Derivatives. LXVI. Reaction of Acetoacetamide with α, β-Unsaturated Esters
• Studies on Ketene and Its Derivatives. LXII. Reaction of Ketene and Diketene with 2-Pyridyl Isocyanate and Isothiocyanate
• Synthesis of Methylpyridine Derivatives. XVI. The Reaction of Picolines and their N-Oxides with Amyl Nitrite.
• Pharmacological Properties of Heterocyclic Amidine Derivatives. II. Pharmacological Studies of Phenylguanylpiperazine Derivatives
• Dopamineの摘出ラット左心房標本に対する作用
• Lithium塩の薬理学的研究(第3報)　―塩化リチウム(LiCl)の循環系および平滑筋におよぼす一般薬理作用―
• Synthesis of 1-Substituted-1,2,5,6-tetrahydro-4H-pyrrolo (3,2,1-ij) quinolin-2-one
• Studies on Ketene and Its Derivatives. XXXIX. Reaction of Diketene with Semicarbazone
• Studies on Ketene and Its Derivatives. XXXVIII. Reaction of Diketene with Phenylhydrazones to give 4-Acetyl-2-phenylpyrazolidin-3-ones
• Studies on the Synthesis of Indole Related Compounds. II. Diels-Alder Reaction of Phenacylidene Indolinone
• Synthesis of Methylpyridine Derivatives (XXI). Amination of Chloro-2,6-lutidines and Their N-Oxides via a Hetaryne Mechanism
• N-Oxidation of 4-Chloropyrimidine Derivatives
• Studies on Ketene and Its Derivatives. XXXII. Reactions of α, β-Unsaturated Acid Anhydride with β-Aminocrotonamide and Related Compounds
• Studies on Ketene and Its Derivatives. XII. The Structure of the Self-Condensation Product of Acetoacetamide.
• Reactivities of 4-Chloropyridine Derivatives and Their 1-Oxides.
• Studies on Ketene and Its Derivatives. XXXI. 2-Acetonyloxazolines

もっと見る 閉じる

スポンサーリンク