Synthesis of Methylpyridine Derivatives. XXX. Reaction of Active Methylene Compounds with 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one and 2-Ethoxy-2,6-dimethyl-2H-1,3-oxazin-4 (3H)-one to give 3-Acetylpyridone Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Reaction of 6-methyl-2-phenyl-4H-1,3-oxazin-4-one (I) with active methylene compounds, such as diethyl malonate (IIIa), acetylacetone (IIIb), cyclohexane-1,3-dione (IIIc), malononitrile (IIId), ethyl acetoacetate (IIIe), ethyl cyanoacetoacetate (IIIf), and cyanoacetophenone (IIIg) afforded pyridone derivatives, such as 3-acetyl-5-ethoxy-carbonyl-4-hydroxy-6-phenyl-2 (1H)-pyridone (IVa), 3,5-diacetyl-4-methyl-6-phenyl-2 (1H)-pyridone (IVb), 4-acetyl-1-phenyl-6,7-dihydro-3,8-(2H, 5H)-isoquinolinedione (IVc), 3-acetyl-4-amino-5-cyano-6-phenyl-2 (1H)-pyridone (IVd), 3-acetyl-5-ethoxycarbonyl-4-methyl 6-phenyl-2 (1H)-pyridone (IVe), 3-acetyl-5-cyano-4-hydroxy-6-phenyl-2 (1H)-pyridone (IVf), and 3-acetyl-5-cyano-4,6-diphenyl-2 (1H)-pyridone (IVg), respectively. Similarly, 2-ethoxy-2,6-dimethyl-2H-1,3-oxazin-4 (3H)-one (II) reacted with IIIa-t under the same conditions to give the corresponding pyridone derivatives (Va-f).
- 社団法人日本薬学会の論文
- 1975-08-25
著者
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加藤 鉄三
東北大学 薬
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加藤 鉄三
Pharmaceutical Institute Tohoku University
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山本 豊
Pharmaceutical Institute, Tohoku University
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近藤 正嗣
Pharmaceutical Institute, Tohoku University
-
近藤 正嗣
Pharmaceutical Institute Tohoku University
-
加藤 鉄三
Pharmaceutical Institute. Tohoku University
-
山本 豊
Pharmaceutical Institute Tohoku University
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