ケテンおよびその誘導体の研究(第51報))α-アミノ酸アミドとジケテンとの反応
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概要
- 論文の詳細を見る
Reaction of diketene with glycinamide (IIIa) and its N-substituted derivatives (IIIb-f) afforded 2-acetoacetamidoacetamide (IVa-f) in a good yield. Treatment of IVa-e with sodium methoxide in methanol gave several cyclization products (II, V, VI, VII, , VIII). In the case of IVa-c, the main product was II which is obtainable by the cyclization of ethyl acetoacetylglycine^3)(Ia). On the other hand, disubstituted derivative such as IVd, e gave 3-hydroxy-3-methyl-5-oxopyrrolidine-2-carboxamide (VI, VII) as a main product.
- 公益社団法人日本薬学会の論文
- 1972-12-25
著者
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佐藤 雅之
静岡県立大学薬学部
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加藤 鉄三
東北大学 薬
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加藤 鉄三
東北大学薬学部
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佐藤 雅之
東北大学薬学部
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加藤 鉄三
Pharmaceutical Institute. Tohoku University
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