Reaction of Diketene-Acetone Adduct with Enamines, Ketene Acetals, Vinyl Ethers, and β-Diketones
スポンサーリンク
概要
- 論文の詳細を見る
Diketene-acetone adduct (1) generates acetylketene (2) under heating. In order to compare the reactivity of 2 with that of diketene, the reaction of 1 with electron-rich olefins was investigated. On heating with 1,primary enamines (3a-d) produced the corresponding 3-substituted 2,6-dimethyl-4 (1H)-pyridones (4a-d), while the tertiary enamine 3e gave the 4-pyrone derivative (7). The reaction of 1 with ketene acetals (8) gave the 2,2-diethoxy-2,3-dihydro-4-pyrone derivatives (9). The vinyl ether derivatives 13 similarly reacted with 1 to give the 4-pyrone derivative 15 or 16 as the major product. The result shows that both diketene and 2 react with electron-rich olefins in a similar manner.
- 社団法人日本薬学会の論文
- 1983-12-25
著者
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佐藤 雅之
静岡県立大学薬学部
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加藤 圭子
Pharmaceutical Institute Tohoku University
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酒井 雅子
Pharmaceutical Institute Tohoku University
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佐藤 雅之
Pharmaceutical Institute, Tohoku University
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加藤 鐵三
Central Research Institute Mect Corporation
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加藤 鐵三
Pharmaceutical Institute. Tohoku University
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小笠原 弘道
Pharmaceutical Institute, Tohoku University
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小笠原 弘道
Pharmaceutical Institute Tohoku University
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