Synthesis of β-Ketocarboxamide Derivatives Using 2,2-Dimethyl-2H, 4H-1,3-dioxin-4-ones
スポンサーリンク
概要
- 論文の詳細を見る
Thermal reaction of 2,2-dimethyl-2H, 4H-1,3-dioxin-4-ones (1) with amines was studied. Acylketenes 2,generated by heating of 1,reacted with anilines and benzylamine to give the corresponding β-ketocarboxamides (3,4,and 5) in good yields. The reaction of 1 with ammonia gave 3-amino-2-alkenamides (7), which were hydrolyzed to β-ketocarboxamides (6). The former products 7 were readily transformed to the 6-substituted 2-methyl-3H-pyrimidin-4-ones (9) via the 3-acetamido-2-alkenamides (8). Acylation of O-benzylhydroxylamine with 1 gave the β-ketohydroxamic acids 10. Debenzylation of 10 followed by cyclization gave rise to 5-alkyl-3-hydroxyisoxazoles (12). The reaction of 1 with amides gave the corresponding N-acylated amides (13).
- 公益社団法人日本薬学会の論文
- 1984-10-25
著者
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佐藤 雅之
静岡県立大学薬学部
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佐藤 雅之
Pharmaceutical Institute, Tohoku University
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加藤 鐵三
Central Research Institute Mect Corporation
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加藤 鐵三
Pharmaceutical Institute. Tohoku University
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小笠原 弘道
Pharmaceutical Institute, Tohoku University
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小松 幸子
Pharmaceutical Institute Tohoku University
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小笠原 弘道
Pharmaceutical Institute Tohoku University
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