Studies on Ketene and Its Derivatives. CXII. Reaction of Ketene with Schiff Bases to give α-Unsubstituted β-Lactams

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概要

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• The reaction of ketene with Schiff bases was investigated. Heating of ketene with Schiff bases (1a-l) without solvent gave α-unsubstituted β-lactams (2a-l). The reaction of ketene with ethyl N-furfurylideneglycinate (1k) to give the β-lactam 2k was carried out at various temperatures, and it was found that the yield of 2k was not much influenced by the reaction temperature. β-Lactams (2d, f, k, l) were treated with 10% aqueous sodium hydroxide in dioxane to give the corresponding carboxylic acids (4d, f, k, l) in good yields. Compounds 4d, f, l reacted with various amines in the presence of dicyclohexylcarbodiimide (DCC) to give the corresponding amides (5a-c, 8a-d).

• 公益社団法人日本薬学会の論文
• 1983-02-25

著者

• 加藤 鐵三

  Central Research Institute Mect Corporation

• 加藤 鐵三

  Pharmaceutical Institute. Tohoku University

• 片桐 信弥

  Pharmaceutical Institute, Tohoku University

• 丹羽 龍史

  Central Research Institute Mect Corporation

• 片桐 信弥

  Health Sci. Univ. Hokkaido Hokkaido Jpn

• 片桐 信弥

  Pharmaceutical Institute Tohoku University

• 丹羽 龍史

  Pharmaceutical Institute, Tohoku University

• 三浦 裕

  Pharmaceutical Institute, Tohoku University

• 三浦 裕

  New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.

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