A Facile Synthetic Method for Pyrimidine Acyclonucleoside Derivatives
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概要
- 論文の詳細を見る
A facile synthetic method for pyrimidine acyclonucleosides is described. Bis (trimethylsilyl) ethers of uracils (1-3) react with 2-substituted 1,3-dioxolanes (4) in the presence of a Lewis acid to form 1-[α-(2-hydroxyethoxy) alkyl] uracil derivatives. Treatment of these reaction mixtures with methanol containing sodium hydrogen carbonate or aqueous sodium hydroxide gives pyrimidine acyclonucleosides (5a-g).
- 公益社団法人日本薬学会の論文
- 1985-04-25
著者
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松永 功
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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新藤 実
New Drug Research Laboratories, Chugai Pharmaceutical Co. Ltd.
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宮本 勝仁
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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新藤 実
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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三浦 裕
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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光井 碩樹
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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宮本 勝仁
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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越智 清成
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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越智 清成
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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越智 清成
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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