Semisynthetic β-Lactam Antibiotics. IV. Synthesis and Antibacterial Activity of New Ureidocephalosporin and Ureidocephamycin Derivatives Containing a Catechol Moiety or Its Acetate(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
New ureidocephalosporin and ureidocephamycin derivatives containing a catechol moiety or its acetate were prepared and their minimum inhibitory concentration values against various microorganisms were determined. Among these compounds, the ureidocephalosporins (2, 3Aa, 3Ba) and ureidocephamycins (4, 5) carrying a methyl group on the nitrogen atom of the ureido bond showed strong activities against Pseudomonas aeruginosa. 7β-[(R)-2-[3-(3,4-Dihydroxy-benzoyl)-3-methylureido]-2-phenylacetamido]-7α-methoxy-3-[{1-methyl-1H-tetrazol-5-yl)-thioniethyl]-3-cephem-4-carboxylic acid (5) had the most potent activity in vitro against gramnegative bacteria, its activity being 8- to 32-fold-and 4-fold greater than those of cefoperazone and ceftazidime, respectively, against two strains of P. aeruginosa. The structure activity relationship is discussed.
- 社団法人日本薬学会の論文
- 1987-05-25
著者
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松本 雅彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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OHI NOBUHIRO
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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青木 文弥
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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篠崎 禎造
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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MORO KANZI
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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黒木 俊夫
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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NOTO TAKAO
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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NEHASHI TOSHIYUKI
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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松本 雅彦
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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岡崎 博司
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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松永 功
New Drug Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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Noto Takao
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Moro Kanzi
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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Ohi Nobuhiro
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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青木 文弥
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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Nehashi Toshiyuki
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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岡崎 博司
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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青木 文弥
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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篠崎 禎造
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松永 功
New Drug Research Laboratories Chugai Pharmaceutical Co. Ltd.
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黒木 俊夫
Fuji-gotemba Research Laboratories Chugai Pharmaceutical Company Ltd.
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