Synthetic Studies of Vitamin D Analogues. XVII.Synthesis and Differentiation-Inducing Activity of 1α, 24-Dihydroxy-22-oxavitamin D_3 Analogues and Their 20(R)-Epimers
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概要
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Four vitamin D_3 analogues, 1α, 24(S)-and 1α, 24(R)-dihydroxy-22-oxavitamin D_3 (5 and 6) and their 20(R)-epimers (7 and 8) were synthesized from the 20(S)-alcohol (10). In tests of activity to induce differentiation of human myeloid leukemia cells (HL-60) to macrophages, 5 showed comparable activity to 1α, 25-dihydroxy-22-oxavitamin D_3 (OCT) (2), and the other three analogues (6,7 and 8) were less active than OCT (2). The binding properties of these analogues to the chick embryonic intestinal 1α, 25-dihydroxyvitamin D_3 (1) receptor were evaluated. Furthermore, 20(R)-OCT (9) was synthesized and its biological properties were compared with those of OCT (2) and the 20(R)-epimers (7 and 8).
- 社団法人日本薬学会の論文
- 1993-09-15
著者
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久保寺 登
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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松本 雅彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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渡邉 博義
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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宮本 勝仁
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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松岡 雪
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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河西 武彦
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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渡邊 博義
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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松岡 雪
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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河西 武彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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宮本 勝仁
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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渡邊 博義
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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