Synthetic Studies of Vitamin D Analogues. XI. Synthesis and Differentiation-Inducing Activity of 1α, 25-Dihydroxy-22-oxavitamin D_3 Analogues
スポンサーリンク
概要
- 論文の詳細を見る
Six analogues of 1α, 25-dihydroxy-22-oxavitamin D_3 (OCT) (2), 26,27-dimethyl OCT (5), 26,27-diethyl OCT (6), 24-norOCT (7), 24-homoOCT (8), 24-dihomoOCT (9), and 24-trihomoOCT (10) were synthesized from the 20(S)-alcohol (11) as the common starting material. In the activity inducing differentiation of human myeloid leukemia cells (HL-60) into macrophages, 26,27-dimethyl OCT (5) and 24-homoOCT (8) showed the highest activities. The binding properties of these analogues to the chick embryonic intestinal 1α, 25-dihydroxyvitamin D_3 (1) receptor are also described.
- 社団法人日本薬学会の論文
- 1992-06-25
著者
-
久保寺 登
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
松本 雅彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
河西 武彦
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
渡邊 博義
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
-
河西 武彦
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
-
渡邊 博義
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
関連論文
- Synthetic Studies of Vitamin D Analogues. XVII.Synthesis and Differentiation-Inducing Activity of 1α, 24-Dihydroxy-22-oxavitamin D_3 Analogues and Their 20(R)-Epimers
- Synthetic Studies of Vitamin D Analogues. XI. Synthesis and Differentiation-Inducing Activity of 1α, 25-Dihydroxy-22-oxavitamin D_3 Analogues
- Synthetic Studies of Vitamin D Analogues. X. Synthesis and Biological Activities of 1α, 25-Dihydroxy-21-norvitamin D_3
- Synthetic Studies of Vitamin D Analogues. IX. Synthesis and Differentiation-Inducing Activity of 1α, 25-Dihydroxy-23-oxa-, thia-, and azavitamin D_3
- Semisynthetic β-Lactam Antibiotics. IV. Synthesis and Antibacterial Activity of New Ureidocephalosporin and Ureidocephamycin Derivatives Containing a Catechol Moiety or Its Acetate(Medicinal Chemistry,Chemical)
- Production and Specificity of Anti-22-oxacalcitriol Antisera
- DETERMINATION OF THIOCYANATE, THIOSULFATE, SULFITE AND NITRITE BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED WITH ELECTROCHEMICAL DETECTION
- Synthetic Studies of Vitamin D Analogues. XIV. Synthesis and Calcium Regulating Activity of Vitamin D_3 Analogues Bearing a Hydroxyalkoxy Group at the 2β-Position