Synthetic Studies of Vitamin D Analogues. XIV. Synthesis and Calcium Regulating Activity of Vitamin D_3 Analogues Bearing a Hydroxyalkoxy Group at the 2β-Position
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概要
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Four vitamin D_3 analogues (7a, 7b, 7c and 7d) bearing a hydroxyalkoxy group at the 2β-position were synthesized from the α-epoxide (5). The C-3 analogue (7b) showed the highest potency for elevating plasma calcium levels in rats. Furthermore, the 25-hydroxylated C-3 analogue (ED-71) (3), prepared from the 25-hydroxylated α-epoxide (9), significantly increased plasma calcium to levels much higher than those in rats administered 1α, 25-(OH)_2-D_3 (1).
- 公益社団法人日本薬学会の論文
- 1993-06-15
著者
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久保寺 登
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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宮本 勝仁
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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渡邊 博義
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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宮本 勝仁
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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渡邊 博義
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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村山 栄五郎
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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越智 清成
Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,
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村山 栄五郎
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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越智 清成
Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.
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