Reaction of (R)-(-)-2-Aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum(II) with Guanosine

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概要

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• The reaction of a new antitumor platinum complex, (R)-(-)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum(II) (1) with guanosine a room temperature in an aqueous solution was followed by proton nuclear magnetic resonance (^1H-NMR) spectroscopy and high performance liquid chromatography (HPLC) at intervals. Both techniques showed that a new compound was formed by displacement of the 1,1-cyclobutanedicarboxylate moiety of 1 with two guanosines, and its ^1H-NMR spectrum and HPLC chromatogram were proved to be identical with those of [(R)-(-)-2-aminomethylpyrrolidine]bis(N_7-guanosine)platinum(II) (2), which was obtained upon successive treatment of (R)-(-)-2-aminomethylpyrrolidinedichloroplatinum(II) (3) with AgNO_3 and 2 mol eq of guanosine in water. The binding sites of the platinum to the two guanosine moieties in 2 were confirmed by the pH dependence of the two G-H_8 signals.

• 公益社団法人日本薬学会の論文
• 1989-10-25

著者

• 村田 博

  Drug Development Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 伊東 雅夫

  Drug Development Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 渡辺 芳彦

  Drug Development Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 越智 清成

  Drug Development Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• 本多 成光

  Drug Development Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• 本多 成光

  Drug Development Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 越智 清成

  Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• 越智 清成

  Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.

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