Asymmetric Reduction of 2-Aminobenzophenone Using Yeast, Rhodosporidium toruloides

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概要

• 論文の詳細を見る

• (±)-N-Isonicotinoyl-2-amino-5-chlorobenzhydrol (1) is a rice plant growth regulator which shortens the second leaf sheaths. One of the enantiomers, (S)-1,was obtained by microbiological asymmetric reduction of 2-amino-5-chlorobenzophenone using Rhodosporidium toruloides followed by isonicotinoylation. Several substituted benzhydrol derivatives were also prepared by use of the same biological method and converted to N-isonicotinoyl compounds. The growth-regulating activities of these compounds were evaluated.

• 公益社団法人日本薬学会の論文
• 1991-10-25

著者

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 大石 武

  Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research (Riken Insti

• 越智 清成

  Exploratory Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• 加藤 昌宏

  Production Technology Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 笹原 一夫

  Production Technology Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• 越智 清成

  Production Technology Research Laboratories, Chugai Pharmaceutical Co., Ltd.,

• 越智 清成

  Exploratory Research Laboratories Chugai Pharmaceutical Co. Ltd.

• 笹原 一夫

  Production Technology Research Laboratories Chugai Pharmaceutical Co. Ltd.

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