Syntheses of optically Active (+)-Fragrolide and (+)-Bemadienolide from Dehydroabietic Acid
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概要
- 論文の詳細を見る
14-Hydroxydehydroabietane derivatives (8 and 9), having an oxygen functional group at the 6-position, were obtained from 14-hydroxy-7-oxodehydroabietane (10) by transformation of the 7-oxo group into a 6-acetoxyl (or hydroxyl) group. Ozonolysis of the above phenols (8 and 9) and subsequent reduction gave the 6-oxygenated confertifolin derivatives 17 and 19,respectively. Oxidation of 6-hydroxyconfertifolin (19) afforded the optically active (+)-fragrolide (4). On the other hand, 19 was also converted into (+)-bemadienolide (5) by oxidation of the important intermediate, 6β-phenylselenoconfertifolin (25).
- 社団法人日本薬学会の論文
- 1981-06-25
著者
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穴沢 昭
Rikagaku Kenkyusho (the Institute Of Physical And Chemical Research)
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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秋田 弘幸
Rikagaku Kenkyusho (The Institute of Physical and Chemical Research)
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大石 武
Rikagaku Kenkyusho (The Institute of Physical and Chemical Research)
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