リパーゼを用いる光学活性ヒドロキシエステルの創製とその生理活性化合物合成への応用 : ベンツリシジンA, Bアグリコンの全合成

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概要

• 論文の詳細を見る

• Optically active 2-methyl-3-hydroxy propionic acid derivatives which are expected to be useful building blocks for the synthesis of polyoxo-macrolide antibiotics or the related bioactive compounds have been synthesized based on the asymmetric hydrolysis using various industrialized lipases. As an example of synthetic studies using these synthons, a total synthesis of the aglycone of venturicidins A and B is described.<BR>Hydrolysis of water-insoluble substrates with lipases immobilized with celite or prepolymer (ENTP-4000) proceeds even in organic solvent. However improvement of efficiency is required. Thus a new immobilization method was developed. Namely, an aggregate of lipases with various phospholipid analogue whose hydrophobic aliphatic chains are linked by ether bonding was found to catalyze an asymmetric hydrolysis much more effectively than the previous immobilization methods.

• 社団法人 有機合成化学協会の論文

著者

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 秋田 弘幸

  東邦大学薬学部

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 大石 武

  理化学研究所

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