A Facile Chemoenzymatic Route to Optically Active 4,5-Disubstituted-2E-hexenoate Derivatives. II

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概要

• 論文の詳細を見る

• The reaction of (±) methyl 4,5-trans-epoxy-(2E)-hexenoate (1) with nucleophile having heteroatoms in the presence of BF_3・Et_2 O gave the 4,5-anti-5-hydroxy-4- and/or 2,5-anti-5-hydroxy-2-substituted products. Among them, the (±)-4,5-anti-5-hydroxy-4-thiophenoxy ester 12a was enantioselectively acetylated with acylating reagent in the presence of lipase "PL 266" from Alcaligenes sp. to provide the (4S, 5R)-5-acetoxy ester 12b and (4R, 5S)-12a quantitatively.

• 公益社団法人日本薬学会の論文
• 1993-04-15

著者

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 大石 武

  Riken Institute (The Institute of Physical and Chemical Research)

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 梅澤 勲

  School of Pharmaceutical Science, Toho University

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 鷹野 道香

  Riken Institute(the Insitute Of Physical And Chemical Research)

• 梅澤 勲

  School Of Pharmaceutical Science Toho University

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