The Use of Microorganisms in Organic Synthesis. I. Microbiological Asymmetric Reduction of 2-Methyl-3-oxobutyrates
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概要
- 論文の詳細を見る
The synthesis of optically active α-methyl β-hydroxy esters I by means of microbiological reduction of the corresponding β-keto esters II was carried out. Benzyl 2-methyl-3-oxobutyrate 1 was found to be reduced by a variety of yeasts to the α-methyl β-hydroxy esters with (2R, 3S)- and (2S, 3S)-configurations (2 and 3,respectively), and by carrying out screening experiments, yeasts which give each product with high optical purity were isolated. Moreover, the absolute configuration and the optical purity of the reduction products were found to be determinable from the 400 MHz nuclear magnetic resonance spectra of the (+)-α-methyoxy-α-trifluoromethylphenylacetyl esters of the alcohols produced.
- 公益社団法人日本薬学会の論文
- 1983-12-25
著者
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堀越 弘毅
Laboratory Of Bacteriology And Ecology The Institute Of Physical And Chemical Research (riken Instit
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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越地 弘子
Synthetic Organic Chemistry Laboratory The Institute Of Physical And Chemical Research (riken Instit
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大石 武
Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research (Riken Insti
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古市 昭也
Synthetic Organic Chemistry Laboratory The Institute Of Physical And Chemical Research (riken Instit
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