A FORMAL SYNTHESIS OF l-α-SANTONIN FROM CHIRAL α, β-EPOXYEUDESMANOLIDE VIA ENZYME-CATALYZED HYDROLYSIS

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概要

• 論文の詳細を見る

• (4S, 5R)-Epoxy-(3S)-hydroxy-(10S)-7α, 11βH-eudesman-6α, 12-olide 4__- and (4R, 5S)-epoxy-(3S)-hydroxy-(10R)-7β, 11αH-eudesman-6β, 12-olide 5__- were obtained from (±)-3__- using yeast and (3S)-acetoxy-(4S, 5R)-epoxy-(10S)-7α, 11βH-eudesman-6α, 12-olide 8__- was produced from (±)-8__- using lipase, respectively. New total syntheses of l-α-santonin (9) and its Δ^<4(14)>-isomers (10 and 11) were accomplished by a short step synthesis using the optically active key intermediate (10S)-8__- (prepared by asymmetric hydrolysis of (±)-8__-).

• 公益社団法人日本薬学会の論文
• 1994-05-15

著者

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 大石 武

  Meiji College Of Pharmacy

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 清水 信子

  Pharmaceutical Institute, School of Medicine, Keio University

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• 清水 信子

  Pharmaceutical Institute School Of Medicine Keio University

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