微生物, 酵素機能を用いる有機合成.ベンツリシジンA, Bアグリコンの全合成

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概要

• 論文の詳細を見る

• The synthesis of chiral synthons by means of microbial and enzymatic function and its application to the synthesis of complex, bioactive substances, the aglycone of venturicidins A and B are reviewed. 1) The syntheses of chiral synthons having two chiral centers are described based on the microbial asymmetric reduction of α-methyl β-keto esters or enzymatic asymmetric hydrolysis of α-methyl β-acetoxy esters. 2) The new chiral synthons synthesized in 1) have been successfully applied for the total syntheses of oudemansins A and B. 3) Purification and properties of the asymmetric reduction enzyme of α-methyl β-keto esters in Saccharomyces cerevisiae or Saccharomyces fermentati were investigated. 4) Formal total synthesis of (-)-indolmycin is described based on the asymmetric hydrolysis of α-acetoxy ester with lipases. 5) Enzymatic hydrolysis in organic solvents for kinetic resolution of water-insoluble α-acyloxy esters with immobilized lipases is described. 6) The first total synthesis of the aglycone of venturicidins A and B has been successfully achieved from the new chiral synthon based on the developed method in 1).

• 公益社団法人日本薬学会の論文
• 1990-11-25

著者

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

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