Microbiologically Modified Chiral Synthon. III. 4,9-Dimethyl-3,5-dioxo-Δ^<4(10)>-octalin for Formal Total Syntheses of Certain Sesquiterpenoids

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概要

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• Microbiological enantioselective transformation of 4,9-dimethyl-3,5-dioxo-Δ^<4(10)>-octalin, (±)-1 was accomplished with various yeasts, e.g. Rhodotorula rubra. With properly selected microorganisms, (+)-4,9S-dimethyl-5S-hydroxy-(2a) and (-)-4,9R-dimethyl-5S-hydroxy-3-oxo-Δ^<4(10)>-octalin (3b), (-)-4,9R-dimethyl-3S-hydroxy- (6b) and (+)-4,9S-dimethyl-3S-hydroxy-5-oxo-Δ^<4(10)>-octalin (7a) were obtained with high optical purity.These compounds have now become available for the total syntheses of sesquiterpenoids such as tuberiferine and temisin.

• 公益社団法人日本薬学会の論文
• 1991-11-25

著者

• 大倉 多美子

  Pharmaceutical Institute School Of Medicine Keio University

• 飯高 洋一

  Nishi-tokyo Science University

• 秋田 弘幸

  School of Pharmaceutical Sciences, Toho University

• 大石 武

  Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy

• 稲山 誠一

  Pharmaceutical Institute, School of Medicine, Keio University

• 飯高 洋一

  School Of Medicine Teikyo University

• 飯高 洋一

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 飯高 洋一

  西東京科学大学理工学部

• 大石 武

  理研:(現)明治薬科大学

• 秋田 弘幸

  School Of Pharmaceutical Science Toho University

• 秋田 弘幸

  理化学研究所

• 飯高 洋一

  Department of Pharmaceutical Sciences, Kobe Gakuin University

• 清水 信子

  Pharmaceutical Institute, School of Medicine, Keio University

• 秋田 弘幸

  Institute of Physical and Chemical Research

• 大石 武

  Institute of Physical and Chemical Research

• 稲山 誠一

  Institute Of Oriental Medical Sciences

• 稲山 誠一

  Pharmaceutical Institute School Of Medicine Keio University

• 稲山 誠一

  慶應義塾大学医学部薬化学研究所

• 清水 信子

  Pharmaceutical Institute School Of Medicine Keio University

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