A Facile Chemoenzymatic Route to Optically Active 4,5-Disubstituted-2E-hexenoate Derivatives. I
スポンサーリンク
概要
- 論文の詳細を見る
The reaction of (±) methyl 4,5-trans-epoxy-2E-hexenoate (2) with aromatic nucleophiles having an electrondonating group in the presence of BF_3・Et_2O gave the 4,5-anti-5-hydroxy-4- or/and 2,5-anti-5-hydroxy-2-substituted products. The 5-acetates of the 4,5-anti-4-substitution products were subjected to enantioselective hydrolysis with lipase to provide the optically acitive 4,5-disubstituted 2-hexenoate derivatives.
- 社団法人日本薬学会の論文
- 1993-01-15
著者
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秋田 弘幸
School of Pharmaceutical Sciences, Toho University
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松倉 弘子
Riken Institute (The Institute of Physical and Chemical Research)
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大石 武
Riken Institute (The Institute of Physical and Chemical Research)
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松倉 弘子
Riken Institute(the Institute Of Physical And Chemical Research)
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大石 武
Faculty Of Engineering Yokohama National University:(present Address)meiji College Of Pharmacy
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梅澤 勲
School of Pharmaceutical Science, Toho University
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大石 武
理研:(現)明治薬科大学
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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鷹野 道香
Riken Institute(the Insitute Of Physical And Chemical Research)
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大山 智以子
Riken Institute(The Insitute of Physical and Chemical Research)
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梅澤 勲
School Of Pharmaceutical Science Toho University
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