The Use of Microorganisms in Organic Synthesis. IV. Microbiological Asymmetric Reduction of Methyl 3-Phenyl 2-Oxobutyrate
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概要
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The synthesis of optically active α-hydroxy β-methyl esters V by means of microbiological reduction of the corresponding α-keto β-methyl esters IV was carried out. Methyl 3-phenyl-2-oxobutyrate 3 was found to be reduced by a variety of yeasts to the α-hydroxy β-methyl esters (7b and 8a) with (2R, 3S)-and (2R, 3R)-configurations, respectively, and by carrying out screening experiments, yeasts which give products with high optical purity were actually found.
- 公益社団法人日本薬学会の論文
- 1984-04-25
著者
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堀越 弘毅
Laboratory Of Bacteriology And Ecology The Institute Of Physical And Chemical Research (riken Instit
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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越地 弘子
Synthetic Organic Chemistry Laboratory The Institute Of Physical And Chemical Research (riken Instit
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古市 昭也
Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research (Riken Insti
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秋田 弘幸
Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research (Riken Insti
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大石 武
Synthetic Organic Chemistry Laboratory, The Institute of Physical and Chemical Research (Riken Insti
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古市 昭也
Synthetic Organic Chemistry Laboratory The Institute Of Physical And Chemical Research (riken Instit
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