Enzymatic Procedure for the Synthesis of 11-Deoxyprostaglandins(Organic,Chemical)
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概要
- 論文の詳細を見る
This paper describes the enzymatic hydrolysis of the trans, trans(meso)-2-substitiued 1,3-bis(acetoxymethyl)cyclopentanes (4a, b) to afford the monoacetates (5a, b) in high enantiomeric excess ((-)-5a: 96%ee, (-)-5b: >99%ee). The absolute stereochemistry of (-)-5b was unequivocally determined to be 1R,2R,3S by converting it to a known compound derived from (-)-limonen-10-ol. Starting with (-)-5b, a new route to the key intermediate ((-)-20) for the synthesis of 11-deoxyprostaglandins was established.
- 公益社団法人日本薬学会の論文
- 1987-05-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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岡野 耕二
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
九州大学薬学部
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秋田 弘幸
School Of Pharmaceutical Science Toho University
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秋田 弘幸
理化学研究所
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岡野 耕二
Life Science Research Laboratory Japan Tobacco Inc.
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末宗 洋
九州大学大学院薬学府
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秋田 弘幸
The Institute of Physical and Chemical Research (Riken)
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末宗 洋
九州大学大学院薬学研究院
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