Enzymatic Hydrolysis of 2,2-Bis(acetoxymethyl)cycloalkanones, and Its Application to Formal Synthesis of (-)-Malyngolide
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概要
- 論文の詳細を見る
Asymmetric hydrolysis of 2,2-bis(acetoxymethyl)cyclopentanone (5) using biocatalysis and its application to a formal synthesis of (-)-melyngolide are described. For the asymmetric induction at the quanternary carbon of 5,cholinesterase from electric eel was found to be effective to afford the (+)-monoacetate (6) (90%ee). Compound (+)-6 was easily converted to the synthetic intermediate (28) for (-)-malyngolide.
- 社団法人日本薬学会の論文
- 1988-11-25
著者
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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原部 哲治
Faculty Of Pharmaceutical Sciences Kyushu University
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謝 卓峰
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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謝 卓峰
九大・薬
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末宗 洋
九州大学薬学部
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末宗 洋
九州大学大学院薬学府
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末宗 洋
九州大学大学院薬学研究院
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