Synthesis of 6a-Carbaprostaglandin I_3
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概要
- 論文の詳細を見る
A synthesis of 6a-carbaprostaglandin I_3 (2) was achieved in which the ω-chain was introduced by Wittig reaction of the optically active aldehyde (3) with the β-oxido ylid (4), followed by removal of the protecting groups to afford a chromatographically separable mixture of the 13 (E)-product (8) and its 13 (Z)-isomer (7). The geometry of the double bond was determined by direct comparison of 8 with a standard sample synthesized by an alternative route (Chart 2). Compound 8 was easily transformed into 2 by a 6-step sequence of reactions (Chart 3). By using a similar technique, (13Z)-6a-carbaprostaglandin I_3 (1A) was also synthesized from the 13 (Z)-isomer (6).
- 公益社団法人日本薬学会の論文
- 1984-12-25
著者
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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酒井 浄
三共中研
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小島 孝一
Chemical Research Laboratories, Sankyo Co., Ltd.
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雨宮 茂雄
Chemical Research Laboratories Sankyo Co., Ltd.
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小島 孝一
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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酒井 浄
Japan And Faculty Of Pharmaceutical Sciences Kyushu University
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雨宮 茂雄
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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