A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
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概要
- 論文の詳細を見る
A new synthetic route to optically active α, β-, β', γ'-unsaturated alcohols was established. The chiral enones (6 and 8), prepared from dimethyl malate via chiral phosphonates (4 and 5), were diastereoselectively reduced with Zn(BH_4)_2 to afford the 1,3-syn derivatives (9 and 11). As an application of this 1,3-asymmetric induction, the fungitoxic C-18 hydroxy unsaturated fatty acid isolated from stromata of Epichloe typhina was synthesized.
- 社団法人日本薬学会の論文
- 1989-10-25
著者
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藤本 勝彦
Hanno Research Center Taiho Pharmaceutical Co. Ltd.
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樫原 宏
Faculty of Pharmaceutical Sciences, Kyushu University
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末宗 洋
Faculty of Pharmaceutical Sciences, Kyushu University
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藤本 勝彦
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty of Pharmaceutical Sciences, Kyushu University
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酒井 浄
Faculty Of Pharmaceutical Sciences Kyushu University
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末宗 洋
九州大学薬学部
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末宗 洋
九州大学大学院薬学府
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樫原 宏
Faculty Of Pharmaceutical Sciences Kyushu University
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堅原 宏
Faculty Of Pharmaceutical Sciences Kumamoto University
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末宗 洋
九州大学大学院薬学研究院
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