A Facile Preparation of 4-Thiazolone Derivatives from Thioamides and Various Haloacyl Halides in a Biphase System

スポンサーリンク

概要

• 論文の詳細を見る

• The reaction of thioamides (1) with various haloacyl halides (2,7,11,14,17,and 19) was carried out in sat. NaHCO_3-CH_2Cl_2 and 5% NaOH-CH_2Cl_2 to give several kinds of 4-thiazolones (3-5,10,12 and 15), thiazin-4-one (18) and spiro compounds (21).

• 公益社団法人日本薬学会の論文
• 1985-08-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 堅原 宏

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 樫原 宏

  Faculty Of Pharmaceutical Sciences Kyushu University

• 堅原 宏

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 大川原 正

  Faculty Of Pharmaceutical Sciences Kumamoto University

関連論文

• A New Synthetic Route to Optically Active α, β- and β', γ'-Unsaturated Alcohols, and Its Application to the Synthesis of a Fungitoxic C-18 Hydroxy Unsaturated Fatty Acid
• Facile Synthesis of Furan Derivatives
• Studies on Antitumor Substances. XIV. Syntheses of Bisquarternary Ammonium Salts and the Reaction with Nucleophiles
• Studies on Antitumor Substances. VII. Reaction of N-Amidino-O-alkylisourea with Some Carboxylic Esters
• The Mechanism for the Reaction of Biguanides with Diethyl Oxalate
• Syntheses of New Pyrazoline Derivatives
• Studies on Antitumor Substances. VI. Chemical Behaviors of Thiosulfonates, Disulfonyl Sulfides, and Related Compounds.
• Studies on Antitumor Substances. V. Reaction of Thiosulfonates with Active Methylene Compounds.
• Facile Reduction of Intermediates from Carboxylic Acids and 6-Nitro-1-(2-nitrophenylsulfonyloxy)benzotriazole with Sodium Borohydride to Alcohols
• The Reaction of 1,3-Disubstituted Thioureas with α, ω-Dibromoacyl Chlorides and the Formation of Spiro Compounds
• Reactions of p-Toluenesulfinic Acid with Dialkoxy or Diamino Sulfides and Disulfides
• A Facile Preparation of 4-Thiazolone Derivatives from Thioamides and Various Haloacyl Halides in a Biphase System
• Facile Preparations of 1,4-(Diphenylmethyleneamino) piperazine-2,5-diones and N-Phenylmethyleneamino-β, γ, and δ-lactams from Benzylidene Hydrazines and α, β, γ, and δ-Haloacyl Halides
• Reaction of Biguanides and Related Compounds. XV. Cyclizations of Arylbiguanides and 2-Guanidinobenzimidazole with Bifunctional Unsaturated Dicarboxylates to s-Triazines and Imidazolines
• Behavior of Sulfinic Acid toward N-Chloramines and Related Compounds
• Facile Formation of 1,3-Disubstituted 2,3,5,6-Tetrahydro-2-thioxopyrimidin-4 (1H)-ones and 2-N, 3-Disubstituted 2,3,5,6-Tetrahyro-2-imino-1,3-thiazin-4-ones from Thioureas and β-Haloacyl Halides
• Convenient One-pot Syntheses of Sulfinates, Sulfinamides, and Thiosulfinates by Sulfinylation with p-Toluenesulfinic Acid and Activating Reagents
• A One-Pot Synthesis of β-Lactams by the Reaction of β-Haloacyl Chlorides with α-Amino Acids
• Convenient Syntheses of Cyclic Carboxamides from α, β, γ, δ and ε-Halocarboxamides under Phase Transfer Conditions
• Direct Conversion of Sulfinic Acid to Sulfonic Acid Derivatives
• Thermal Dimerization of Sulfinyl Compounds
• Novel One-step Preparation of Sulfinic Acid Derivatives from Sulfinic Acid
• Asymmetric Synthesis of β-Amino-α, α-dimethyl-β-phenylpropionic Acid. The Reactions of Chiral Schiff Bases with Dimethylketene and with Reformatsky Reagent
• Asymmetric Syntheses of β-Amino Acids by the Reduction of Enamines
• Reaction of Epoxides. VI. Reaction of 2,3-Epoxypropyl Aryl Ether with Ethyl-N-phenylformimidate and N, N'-Diphenylformamidine
• Reaction of Biguanides and Related Compounds. XIV. Cyclization of Amidinothioureas with Some Carbonyl Compounds
• Asymmetric Syntheses of β-Amino Acid and Aspartic Acid by Reformatsky Reaction
• Asymmetric Syntheses of β-Amino Acids by the Addition of Chiral Amines to C=C Double Bonds
• Behaviors of N-(Substituted thio) phthalimides, N-(Substituted thio)-succinimides, and N-(Substituted thio) isatins toward Some Nucleophiles
• Reaction of Biguanides and Related Compounds. XIII. Benzilic Acid Rearrangement. The Reactions of 1,2-Cyclohexanedione and 9,10-Phenanthrenequinone with Arylbiguanides and N-Amidino-0-alkylisoureas
• Conversion of Bis (β-carbamoylethyl) Disulfides into Bis (β-carbamoylethyl) Trisulfides
• Reaction of Biguanides and Related Compounds. XII. Condensations of Arylbiguanides and Amidinoisoureas with Isatins
• Pyrazolines and Oxazolines. Reaction of Arylcarbonylethylthiosulfates with Hydrazines and Hydroxylamines
• Reaction of Epoxides. V. 1,3-Dipolar Cycloaddition Reaction of Epoxides with Carbon-Nitrogen Double Bond Compounds
• Reaction of Biguanides and Related Compounds. X. Formation of s-Triazinethiones by the Condensation of Arylbiguanides with 2,3-Trithiocarbonates
• Thiation of Enamine of Cyclohexanone with Arensulfenamides
• Reaction of Biguanides and Related Compounds. IX. Condensation of N-Amidino-O-alkylisourea and 1-Substituted 3-Amidino-2-thiourea with Benzil
• Reaction of Biguanides and Related Compounds. VIII. The Condensation of Arylbiguanides and N-Amidino-O-alkylisoureas with Diketene and Ethyl Acetoacetate
• The Reaction of Benzyl Phenylmethanethiosulfinate with Amines
• Reaction of Epoxides. IV. Addition of 2,3-Epoxypropyl Phenyl Ether to Oximes and Hydrazones
• Criss-cross Cycloaddition of Epoxides to Aromatic Aldazines
• Arylthiation of Cyclohexanone Morpholine Enamine with Aryl Benzenethiosulfonates
• A Convenient Synthesis of Pyrazolines from β-Carbonylethylthiosulfates
• Reaction of Biguanides and Related Compounds. VII. The Condensation of Arylbiguanide with α, β-Unsaturated Carboxylic Ester in Dimethylformamide
• Reactions of β-Carbonylethylthiosulfates and β-Carbamoylethyl Disulfides with Amines
• Reaction of Biguanides and Related Compounds. VI. Condensation of N-Amidino-O-alkylisourea with β-Diketone
• Sulfenylation of Morpholine Enamine of Cyclohexanone with Sulfenamides and Thiosulfonates
• Mechanism for the Reaction of Sodium Benzylthiosulfate with Morpholine
• Novel Synthesis of Indan Derivatives
• Antiviral Effect and Syntheses of 4-Amino-6-alkylamino-s-triazine-2-carboxylic Acid Derivatives. Researches on Chemotherapeutic Drugs against Viruses. XXXVI.
• Syntheses of Compounds related to Guanidine and their Inhibitory Action on Growth of HeLa Cells.
• Reaction of Epoxides. II. Synthesis of Oxazolidine by the Reaction of Epoxide with Schiff Base
• Studies on Antitumor Substances. XII. Synthesis of Bis (2,3-epoxypropyl) amine Derivatives and the Reaction with Some Nucleophiles
• Reactions of Epoxides. I. Synthesis of Trithiocarbonate by the Reaction of Epoxide with Alkali Xanthate
• Studies on Antitumor Substances. XI. Reactions of Bunte Salts with Nucleophiles
• Formation of Trisulfide from Thiosulfonate with Amine Catalyst
• Reaction of Disulfide and Trisulfide with N-Chlorocarboxamide
• Reaction of Biguanides and Related Compounds. III. Reaction of Biguanide and Amidinoisourea with Oxamate
• Reaction of Biguanides and Related Compounds. II. Reaction of Biguanides with Benzil
• Reaction of Biguanides and Related Compounds. I. Reaction of Biguanides with β-Diketone
• Studies on Antitumor Substances. XIII. Reaction of Sodium Ethoxycarbonylmethylthiosulfate and Sodium Phenacylthiosulfate with Amine
• Reaction of N-Amidinoamidine with Diethyl Oxalate and Ethyl Oxamate
• Studies on Application of Amino Acid as Medicinal Agent. II. Reaction of Amino Acid Ester with Difunctional Grignard Reagent
• Studies on Antitumor Substances. X. Reactions of Thiosulfonates with Some Nucleophilic Compounds
• Studies on Antitumor Substances. IX. Chemical Behaviors of Thiosulfonate toward Active Methylene Compound
• Studies on Antitumor Substances. VIII. Syntheses of 4-Amino-6-substituted Amino-2-substituted sym-Triazine Derivatives
• Studies on Application of Amino Acid as Medicinal Agent. I. Syntheses of Amino-tert-alcohol Derivatives
• Reaction of Epoxides. III. The Synthesis of 2-Amino-5-substituted 4,5-Dihydrothiophene from Substituted Propylene Sulfides and Ethyl Cyanoacetate
• Reaction of Biguanides and Related Compounds. V. The Base-catalyzed Condensation of Benzil with 1,1-Dialkylguanidine
• Reaction of Cyclic Trithiocarbonate with Amine and Phenylhydrazine
• Reaction of Biguanides and Related Compounds. IV. Reaction of Arylbiguanide with Benzoylacetone in the Presence of a Small Amount of the Arylbiguanide Hydrochloride
• A Stereoselective Synthesis of α-Chloro-α-phenylacetamide by the Reaction of optically Active Schiff Base with Dichlorocarbene
• The Conversion of α-Carbonylmethylthiosulfates into Thiocarboxamides
• Antitumor Effects of Pentamethylene Bismethanethiosulfonate Hydrolysates and Difunctional Bunte Salt
• Syntheses and Antiviral Effects of 3-Amino-6-alkyl-as-triazin-5-ol Derivatives.
• Syntheses of 4,6-Diamino-s-triazine-2-carboxamide Derivatives.
• Researches on Chemotherapeutic Drugs Against Viruses. XXXV. Syntheses and Antiviral Activity of Alkylated Ephedrine and its Related Compounds.
• Reaction of 1-Arylbiguanide with Some Carboxylic Esters.
• Studies on Syntheses of Dimethylated Ephedrine Derivatives.

もっと見る 閉じる

スポンサーリンク