Studies on Antitumor Substances. X. Reactions of Thiosulfonates with Some Nucleophilic Compounds

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概要

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• Reactivities of mono and difunctional thiosulfonates toward several nucleophilic compounds, such as thiols, amines and the related compounds, were examined. In the result, some chemical behaviors unexpected were found in addition to the reactivity anticipated. Namely, in the reaction with piperazine, aralkyl thiosulfonate afforded aralkyltrisulfide in about 20% yield, without any formation of sulfenamide. Moreover, aromatic thiosulfonate gave a comparable good yield of 1-phenyl-2-arylsulfonylhydrazine in the reaction with phenylhydrazine, in addition to the formation of phenylhydrazinium salt of aromatic sulfinic acid.

• 公益社団法人日本薬学会の論文
• 1969-05-25

著者

• 古川 潮

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 林 清五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 藤野 洋子

  Institute for Medical and Dental Engineering, Tokyo Medical and Dental University

• 藤野 洋子

  Faculty of Pharmaceutical Sciences, Kumamoto University

• 藤野 洋子

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• 松倉 迅

  Dainippon Seiyaku Co., Ltd.

• 林清 五郎

  Faculty Of Pharmaceutical Sciences Kumamoto University

• 松倉 迅

  Dainippon Seiyaku Co. Ltd.

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