The Conversion of α-Carbonylmethylthiosulfates into Thiocarboxamides
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概要
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The reaction of sodium phenacylthiosulfate with amine was found to form acetophenone as by-product and elucidated to proceed through the intermediate formation of diphenacyl disulfide. The reaction between sodium ethoxycarbonylmethylthiosulfate with cyclohexylamine was also confirmed to proceed analogously through the formation of diethoxycarbonylmethyl disulfide, but not sodium cyclohexylcarbamoylmethylthiosulfate and dicyclohexylcarbamoylmethyl disulfide, to give N, N'-dicyclohexylthiooxamide and cyclohexylammonium cyclohexylaminothiocarbonylcarboxylate. Furthermore, the salt was proved to be formed via the intermediate ethoxycarbonyl-N-cyclohexylthiocarboxamide, but not by hydrolysis of N, N'-dicyclohexylthiooxamide.
- 公益社団法人日本薬学会の論文
- 1972-09-25
著者
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古川 潮
Faculty Of Pharmaceutical Sciences Kumamoto University
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林 清五郎
Faculty Of Pharmaceutical Sciences Kumamoto University
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白石 建三
Fujisawa Co., Ltd.
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白石 建三
Faculty of Pharmaceutical Sciences, Kumamoto University
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林清 五郎
Faculty Of Pharmaceutical Sciences Kumamoto University
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白石 建三
Fujisawa Co. Ltd.
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